THIS PLANT MAY HELP IMPROVE COGNITION IN PEOPLE WITH ALZHEIMER’S DISEASE

December 4, 2017

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“By the time you’re eighty years old you’ve learned everything. You only have to remember it.” So said George Burns, and he hit upon a tender point. Memory loss and cognitive decline are one of the most troubling aspects of growing old today.

 

We now have the medical expertise to extend the average lifespan to over 80, but now more than 5 million Americans are living with Alzheimer’s and by 2050 this number could rise as high as 16 million.

 

Alzheimer’s disease is the most common form of dementia; it irreversibly destroys brain cells, affecting cognition, emotions, mood, behavior and physical capabilities.

 

Topping the known risk factors are diabetes, high blood pressure, and obesity. It’s no wonder Alzheimer’s is so prevalent! Add to these smoking (thankfully on the decline), depression, cognitive and physical inactivity, and you can see why so many of us will experience old age through the lens of confusion.

 

The Moringa oleifera plant is highly regarded by dieticians and medical researchers and practitioners due to its superior nutritional content and numerous medical applications. The antioxidant properties of the moringa plant have been well established by previous medical studies and are believed to provide protection against the effects of free radicals that can cause aging and other negative health effects. Recent studies suggest that moringa leaves can also provide protection against the symptoms of Alzheimer’s disease and may even delay its onset.

 

Research on the cognitive-related healing capabilities of Moringa Oleifera has confirmed ancient folklore of this miracle plant, which has been used for thousands of years, to treat cognitive dysfunction. This scientifically proven ability gives new hope for people suffering from Alzheimer’s Disease.

 

Previous research has shown that Moringa oleifera is able to alter brain monoamines, which have a role in memory processing. Interestingly, people diagnosed with Alzheimer’s disease have their monoaminergic systems disturbed. An AD rat model study investigated whether Moringa oleifera supplementation could alter brain monoamines (norepinephrine, dopamine, and serotonin) in different areas of the brain affected by AD. They found that after moringa oleifera supplementation, the monoamines levels of the brain regions affected by AD were restored to near control levels.

 

The hippocampus plays an important role on spatial memory, and people diagnosed with Alzheimer disease have an altered neurogenesis, a process that happens in the hippocampus, by which neurons are generated from neural stem cells and progenitor cells. This dysfunction in the hippocampus is associated with Cognitive Impairment. However, supplementation with Moringa Oleifera leaves, in a rat model research, has discovered that after being administered 100mg/kg, the animals were able to retain and acquire knowledge, which is a proof of the possible neuroprotective effects of Moringa Oleifera.

 

Here is how Moringa oleifera acts on the brain of people with Alzheimer’s disease

It is important to note that the occurrence of Alzheimer’s disease (AD) is associated with the decrease in acetylcholine (ACh) neurotransmitters, which are affected by the enzymes cholinesterases [AChE and BChE] that have been reported to be responsible for the decline or insufficient ACh level in the synaptic gap of AD patients’ brain.

It is also well established that Increased activity of monoamine oxidase enzymes, have been linked with deactivation/reduction of neuroactive amine (dopamine, norepinephrine, and serotonin) and increase in the production of reactive oxygen species, which leads to neurodegenerative disturbances.

However, Moringa Oleifera seeds extract has been shown to have inhibitory abilities towards the enzymes cholinesterases [AChE and BChE] and monoamine oxidase enzymes. This ability to impact such biochemical reactions in the brain, give Alzheimer patients new hope in treating this disease that in the United States alone, affects over 5 million people.

 

READY TO TRY MORINGA?

We say, why wait? Get your prevention on with a daily dose of Moringa leaf.

 

SOURCES:

  1. Adefegha, S. A., Oboh, G., Oyeleye, S. I., Dada, F. A., Ejakpovi, I. and Boligon, A. A. (2017), Cognitive Enhancing and Antioxidative Potentials of Velvet Beans (Mucuna pruriens) and Horseradish (Moringa oleifera) Seeds Extracts: A Comparative Study. Journal of Food Biochemistry, 41: n/a, e12292. doi:10.1111/jfbc.12292
  2. Ray K, Hazra R, Guha D, Central inhibitory effect of Moringa oleifera root extract: possible role of neurotransmitters. Indian Journal of Experimental Biology [01 Nov 2003, 41(11):1279-1284]. (PMID:15332497)
  3. Ganguly, R; Guha, D., Alteration of brain monoamines & EEG wave pattern in rat model of Alzheimer’s disease & protection by Moringa oleifera. Indian Journal of Medical Research; New Delhi Vol. 128, Iss. 6,  (Dec 2008): 744-51.
  4. Mu, Y., & Gage, F. H. (2011). Adult hippocampal neurogenesis and its role in Alzheimer’s disease. Molecular Neurodegeneration, 6, 85. http://doi.org/10.1186/1750-1326-6-85
  5. Kapogiannis, D., & Mattson, M. P. (2011). Perturbed Energy Metabolism and Neuronal Circuit Dysfunction in Cognitive Impairment. Lancet Neurology, 10(2), 187–198. http://doi.org/10.1016/S1474-4422(10)70277-5
  6. Mohan, Mahalaxmi & Kaul, Nidhi & Punekar, Avinash & Girnar, Raksha & Junnare, Pallavi & Patil, Leena. (2005). Nootropic activity of Moringa oleifera leaves. Journal of Natural Remedies. 5. 59-62.
  7. Igado, O.O. and Olopade, J.O. (Dec 2016). A Review on the Possible Neuroprotective Effects of Moringa Oleifera Leaf Extract. Niger. J. Physiol. Sci. 31(December 2016) 183-187.
  8. Bortolato, M., Chen, K., & Shih, J. C. (2008). Monoamine oxidase inactivation: from pathophysiology to therapeutics. Advanced Drug Delivery Reviews, 60(13-14), 1527–1533. http://doi.org/10.1016/j.addr.2008.06.002
  9. Adefegha, S. A., Oboh, G., Oyeleye, S. I., Dada, F. A., Ejakpovi, I. and Boligon, A. A. (2017), Cognitive Enhancing and Antioxidative Potentials of Velvet Beans (Mucuna pruriens) and Horseradish (Moringa oleifera) Seeds Extracts: A Comparative Study. Journal of Food Biochemistry, 41: n/a, e12292. doi:10.1111/jfbc.12292
  10. https://www.alz.org/facts/
  11. https://web.williams.edu/imput/synapse/pages/IA5.html  

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